Infección diseminada por Strongyloides stercoralis en dos receptores de trasplante renal de un único donante
Abstract
La infección por Strongyloides stercoralis a partir de donantes de órganos es infrecuente, pero cuando se presenta genera diversas complicaciones. Se reportan dos casos de estrongiloidiasis diseminada derivado de un único donante cadavérico en dos receptores de trasplante renal. Ambos pacientes se presentaron con síntomas gastrointestinales y síntomas respiratorios más lesiones dermatológicas en región abdominal. El diagnóstico se basó en el hallazgo de larvas en lavado broncopulmonar, lesiones dermatológicas, y aspirado duodenal. A pesar del manejo con albendazol e ivermectina por vía oral el curso clínico fue fatal en uno de ellos. El segundo paciente recibió precozmente ivermectina por vía subcutánea y sobrevivió con falla intestinal persistente.Downloads
References
Mendes T, Minori K, Ueta M, Miguel DC, Allegretti SM. Strongyloidiasis current status with emphasis in diagnosis and drug research. J Parasitol Res. 2017;2017:5056314.
Kim JH, Kim DS, Yoon YK, Sohn JW, Kim MJ. Donor-derived strongyloidiasis infection in solid organ transplant recipients: a review and pooled analysis. Transplant Proc. 2016;48(7):2442-9.
Macguire J. Intestinal nematodes: Strongyloidiasis. In: Mandell GDR, Bennett J, Dolin R, editors. Mandell, Douglas, and Bennett’s principles and practice of infectious diseases. New York: Elsevier/ Churchill Livingstone; 2009. p. 3582-3.
Bannon JP, Fater M, Solit R. Intestinal ileus secondary to Strongyloides stercoralis infection: case report and review of the literature. Am Surg. 1995;61(4):377-80.
Rodrigues MAM, Fróes RC, Anefalos A, Kobayasi S. Invasive enteritis by Strongyloides stercoralis presentando como distress abdominal agudo y bajo terapia con corticoids. Rev Hosp Clin. 2001;56(4):103-6.
Uparanukraw F, Phongsri S, Morakote N. Fluctuations of larval excretion in Strongyloides stercoralis infection. Am J Trop Med Hyg. 1999;60(6):967-73.
Center for Disease Control and Prevention. Parasites - Strongyloides: resources for health professionals [Internet]. Atlanta, GA: US Department of Health and Human Resources, CDC; 2012 [citado el 15 de julio de 2017]. Disponible en: http://www.cdc.gov/parasites/ strongyloides/health_professionals/index.html
Wang C, Xu J, Zhou X, Li J, Yan G, James AA, Chen X. Strongyloidiasis: an emerging infectious disease in China. Am J Trop Med Hyg. 2013;88(3):420-5.
Puthiyakunnon S, Boddu S1, Li Y1, Zhou X1, Wang C1, Li J, et al. Strongyloidiasis--an insight into its global prevalence and management. PLoS Negl Trop Dis. 2014;8(8):e3018 .
Shorman M, Al-Tawfiq JA. Strongyloides stercoralis hyperinfection presenting as acute respiratory failure and Gram-negative sepsis in a patient with astrocytoma. Int J Infect Dis. 2009;13(5):e288-91.
Marty FM, Lowry CM, Rodríguez M, Milner DA, Pieciak WS, Sinha A, et al. Treatment of human disseminated strongyloidiasis with a parenteral veterinary formulation of ivermectin. Clin Infect Dis. 2005;41(1):e5-8.
Rose CE, Paciullo CA, Kelly DR, Dougherty MJ, Fleckenstein LL. Fatal outcome of disseminated strongyloidiasis despite detectable plasma and cerebrospinal levels of orally administered ivermectin. J Parasitol Res. 2009(2009):818296.
Salluh JI, Feres GA, Velasco E, Holanda GS, Toscano L, Soares M. Successful use of parenteral ivermectin in an immunosuppressed patient with disseminated strongyloidiasis and septic shock. Intensive Care Med. 2005;31(9):1292.
Chiodini PL, Reid AJ, Wiselka MJ, Firming R, Foweraker J. Parenteral ivermectin in Strongyloides hyperinfection. Lancet. 2000;355(9197):43-4.
Sander HS. Enterococos resistentes a vancomicina: ¿Infección emergente inminente? Rev Chil Infectol. 2002;19(Suppl 1):S50-S55.
Palau LA, Pankey GA. Strongyloides hyperinfection in a renal transplant recipient receiving cyclosporine: possible Strongyloides stercoralis transmission by kidney transplant. Am J Trop Med Hyg. 1997;57(4):413-5.
Pacanowski J, Santos MD, Roux A, LE Maignan C, Guillot J, Lavarde V, et al. Subcutaneous ivermectin as a safe salvage therapy in Strongyloides stercoralis hyperinfection syndrome: a case report. Am. J. Am J Trop Med Hyg. 2005;73(1):122-4.
Leung V, Al-Rawahi GN, Grant J, Fleckenstein L, Bowie W. Case report: failure of subcutaneous ivermectin in treating Strongyloides hyperinfection. Am J Trop Med Hyg. 2008;79(6):853-5.
Marcos LA, Cabrera R, Machicado JD, Canales M, Terashima A. Distribution of prevalence of Strongyloides stercoralis in Peru (1981-2010): an exploratory study. Rev Peru Parasitol. 2010;18(2):e39-e40.
Sadjadi SA, Damodaran C, Sharif M. Strongyloides stercoralis infection in transplanted patients. Am J Case Rep. 2013;14:205-9.
Abdalhanid BA, Al Abadi AM, Al Saghier MI, Joudeh AA, Shorman MA, Amr SS. Strongyloides stercoralis infection in kidney trasplant recipiejts. Saudi J Kidney Dis Transpl. 2015;26(1):98-102.
Le M, Ravin K, Hasan A, Clauss H, Muchant DG, Pasko JK, et al. Single donor-derived strongyloidiasis in three solid organ transplant recipients: case series and review of the literature. Am J Transplant. 2014;14(5):1199-206.
Roxby AC, Gottleib GS, Limaye AP. Strongyloidiasis in transplant patients. Clin Infect Dis. 2009;49(9):1411-23.
Abanyie FA, Gray EB, Delli Carpini KW, Yanofsky A, McAuliffe I, Rana M, et al. Donor-derived Strongyloides stercoralis infection in solid organ transplant recipients in the United States, 2009-2013. Am J Transplant. 2015;15(5):1369-75.
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Protocolo de trasplante renal 2015 [Internet]. México: INCMNSZ;2015 [citado el 10 de abril de 2017]. Disponible en: http://www.innsz.mx/imagenes/ProtocoloTR-INNSZ-2015-ver-10. pdf
Schwartz BS, Mawhorter SD; AST Infectious Diseases Community of Practice. Parasitic infections in solid organ transplantation. Am J Transplant. 2013;13 Suppl 4:280-303.
1.png)
.png){kind=logo}
