Enterobiasis y Ascariasis en un orfanato de Lima. Tratamiento masivo con dosis única de pamoato de pirantel

Abstract

We report the results of mass treatment, with respect to Enterobius vermicularis and Ascaris lumbricoides of 1,627 people in a Lima orphanage, with a single oral dose of pyrantel pamoate. 

A sample of 417 children was chosen at randon to provide confidence limits of over 95%; th GRAHAM scotch tape technique, adequate to detection of Enterobius ova, was performed twice botton before and after treatment in 386 of the selected children; 369 children provided fecal samples which were studied by the following techniques: Direct motile larvae and protozoa), and Rapid Sedimentation (for dense ova, such as Fasciola hepatica); other children failed to provide either the pre-post-treatment samples.

E. vermicularis ova were found in 249 (64.5%) of the 386 children. A. lumbricoides ova were found in 22 of the 369 children.

´Pyrantel pamoate, as a suspension, and at a dose of 10mg per kg body weight, was given in a single da to all people connected with the orphanage. Parasito logical controls, using the same techniques, were perfomed between 7 and 26 days after, the GRAHAM technique being repeated twice within this period for each child.

E. Vermicularis ova were found in 231 children (92.8%) of the 249 first found infested; of the 2 parasitized by A. lumbricoides 21 (95.5%) had were reported in the population subjected to treatment. 

Other reports are reviewed and compared with the present one, and comments made on the advantages of pyrantel pamoate: wide antihelminthi spectrum, easy one-dose oral administration, abscense of secondary effects, and superiority over similar drugs.